CALYCOSIN 毛蕊异黄酮
毛蕊异黄酮(7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one)
CAS: 20575-57-9
化学式: C16H12O5
| 中文名 | 毛蕊异黄酮 |
| 英文名 | 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one |
| 别名 | 毛异黄酮 毛蕊异黄酮 毛蕊异黄酮对照品, 毛蕊异黄酮(标准品) 毛蕊异黄酮(毛异黄酮) 毛蕊异黄酮, 来源于蒙古黄芪 CALYCOSIN 毛蕊异黄酮 |
| 英文别名 | Clycosin CALYCOSIN calycosin Astraisoflavone 3'-HYDROXYFORMONONETIN 7,3'-DIHYDROXY-4'-METHOXYISOFLAVONE 3',7-DIHYDROXY-4'-METHOXYISOFLAVONE 7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one 7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one 3-(3-Hydroxy-4-methoxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one 4H-1-benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)- |
| CAS | 20575-57-9 |
| 化学式 | C16H12O5 |
| 分子量 | 284.26 |
| InChI | InChI=1/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3 |
| InChIKey | ZZAJQOPSWWVMBI-UHFFFAOYSA-N |
| 密度 | 1.420±0.06 g/cm3(Predicted) |
| 熔点 | 245～247℃ |
| 沸点 | 536.8±50.0 °C(Predicted) |
| 闪点 | 205.7°C |
| 蒸汽压 | 3.9E-12mmHg at 25°C |
| 溶解度 | 甲醇: 可溶物1mg/mL，澄清，无色 |
| 折射率 | 1.668 |
| 酸度系数 | 6.94±0.20(Predicted) |
| 存储条件 | Sealed in dry,2-8°C |
| 外观 | 粉末 |
| 颜色 | white to light yellow |
| 物化性质 | 白色结晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于黄芪根茎。 |
| MDL号 | MFCD00210598 |
| 危险品标志 | T - 有毒物品 |
| 风险术语 | 25 - 吞食有毒。 |
| 安全术语 | 45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 |
| 危险品运输编号 | UN 3462 6.1 / PGIII |
| WGK Germany | 3 |
| 海关编号 | 2932996560 |
| 参考资料 展开查看 | 1. 黄翠云 陈静 张凤 等. HPLC-MS/MS测定酒石酸溴莫尼定滴眼液的含量[J]. 海峡药学 2020 v.32;No.241(02):56-58. 2. 支旭然 刘洪涛 吴茵 等. UPLC-MS/MS法同时测定肾康注射液中7个有效成分[J]. 药物分析杂志 2017 037(001):37-42. 3. 刘雪 石晓倩 吴晏杰 等. UPLC法同时测定新安名方脑络欣通中5个活性成分的含量[J]. 贵阳中医学院学报 2020年42卷4期 26-31页 ISTIC 2020. 4. 唐蓉 张依人 陈叶童 蒋龙波 邓常清 邹龙.不同剂量配伍对黄芪-当归中5种化学成分的影响[J].中国实验方剂学杂志 2016 22(23):1-5. 5. 刘杰 何钢 刘贤桂 等. 人工栽培鸡血藤中五种黄酮类物质含量测定[J]. 分子植物育种 2017 015(009):3832-3837. 6. 何昊 许畅 王兴中 苏力 张家旭. 四种不同方法提取黄芪中黄芪甲苷的对比研究[J]. 化工科技(3期):25-28. 7. 石岩, 熊婧, 魏锋,等. 基于机器学习及外部"探针"策略的HPLC保留时间预测的研究[J]. 药物分析杂志, 2019, 39(04):160-165. 8. 周乐, 赵晓莉, 狄留庆,等. 大鼠在体单向肠灌流模型研究毛蕊异黄酮的吸收特征[J]. 南京中医药大学学报, 2014, 30(2):160-163. 9. 王维, 张路阳, 赵子龙,等. 毛蕊异黄酮抑制胶质瘤细胞增殖的机制研究[J]. 沈阳药科大学学报, 2020(8):725-729. 10. 侯美如, 尹珺伊, 王岩,等. 黄芪发酵前后黄酮含量及指纹图谱比较研究[J]. 中国兽药杂志, 2018, v.52(05):52-58. 11. 李欣, 卓冰雨, 祁晓娟,等. 黄芪异黄酮含量与气候因子的灰色关联度和通径分析[J]. 中国中药杂志 2020年45卷14期, 3407-3413页, MEDLINE ISTIC PKU CSCD CA BP, 2020. 12. 尚兴朴,欧阳罗丹,肖苏萍,王继永,高永坚,袁春平,刘畅.黄芪饮片质量评价和分级标准探讨[J].中国现代中药,2020,22(05):772-779. 13. 姚静, 施钧瀚, 桂新景,等. 基于HPLC指纹图谱评价的当归补血汤传统汤剂与配方颗粒汤剂的成分差异分析[J]. 中草药, 2019(11). 14. 张倩,杨怀瑾,周悦,余亦婷,庄欣雅,毛春芹,谢辉,李林,陆兔林,严国俊.基于传统煎药工艺的黄芪药材HPLC指纹图谱及化学计量学质量评价研究[J].中草药,2021,52(04):1128-1134. 15. 敏,王猛猛,吴雨,陈文文,王之通,张磊阳,蒋健.补中益气汤6个成分在大鼠体内的药代动力学研究[J].辽宁中医杂志,2020,47(11):159-163. 16. 毛文点,庹玲玲,齐文续,苏睿智,邓常清,邹龙.黄芪-当归不同配伍对其6种主要有效成分溶出的影响[J].湖南中医药大学学报,2021,41(03):350-354. 17. 王维,张路阳,赵子龙,张东勇,包义君.毛蕊异黄酮抑制胶质瘤细胞增殖的机制研究[J].沈阳药科大学学报,2020,37(08):725-729+755. 18. 孙秀蕊,魏桂杰,王宏雅,赵雯雯,张哲,张婷,魏锋,张玉杰.基于外观性状和内在成分的黄芪药材质量等级评价[J].中国中药杂志,2021,46(04):966-971. 19. 张丽,卞晓坤,赵秋龙,钱大玮,郭盛,严辉,欧阳臻,赵建军,段金廒.基于多元成分的黄芪药材产地现代干燥加工方法[J].中国现代中药,2020,22(10):1684-1688. 20. 冯紫薇. 子洲黄芪饮片质量等级标准研究[D].北京中医药大学,2020. 21. Li, Fei, et al. "Effects of Astragalus combined with Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide in mice." Biological and Pharmaceutical Bulletin 40.5 (2017): 598-609.https://doi.org/10.1248/bpb.b16-00802 22. Xing-Yan, L. I. U., et al. "Identification of active compound combination contributing to anti-inflammatory activity of Xiao-Cheng-Qi Decoction via human intestinal bacterial metabolism." Chinese journal of natural medicines 16.7 (2018): 513-524.https://do 23. Yang, Zhenzhong, et al. "Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe." Journal of Pharmaceutical Analysis (2020).https://doi.org/10.1016/ 24. [IF=4.759] Yuping Zhang et al."On-line surface plasmon resonance-high performance liquid chromatography–tandem mass spectrometry for analysis of human serum albumin binders from Radix Astragali."J Chromatogr A. 2013 Jun;1293:92 25. [IF=3.935] Nan Mi et al."Metabolite profiling of traditional Chinese medicine formula Dan Zhi Tablet: An integrated strategy based on UPLC-QTOF/MS combined with multivariate statistical analysis."J Pharmaceut Biomed. 2019 Feb;164:70 26. [IF=3.361] Taofang Cheng et al."Hybrid multidimensional data acquisition and data processing strategy for comprehensive characterization of known, unknown and isomeric compounds from the compound Dan Zhi Tablet by UPLC-TWIMS-QTOFMS."Rsc Adv. 2019 Mar;9(16):8714-8727 27. [IF=3.205] Min He et al."Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC–MS/MS: Application to a tissue distribution study."J Chromatogr B. 2017 Feb;1044-1045:177 28. [IF=2.894] Lulu Lu et al."Calycosin promotes lifespan in Caenorhabditis elegans through insulin signaling pathway via daf-16, age-1 and daf-2."J Biosci Bioeng. 2017 Jul;124:1 29. [IF=2.233] Fei Li et al."Effects of Astragalus Combined with Angelica on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice."Biol Pharm Bull. 2017 May;40(5):598-609 30. [IF=6.529] Xiaoguang Lu et al."Calycosin attenuates doxorubicin-induced cardiotoxicity via autophagy regulation in zebrafish models."Biomed Pharmacother. 2021 May;137:111375 31. [IF=5.81] Gu Junfei et al."Standardized Astragalus Mongholicus Bunge-Curcuma Aromatica Salisb. Extract Efficiently Suppresses Colon Cancer Progression Through Gut Microbiota Modification in CT26-Bearing Mice."Front Pharmacol. 2021 Aug;0:2278 32. [IF=5.455] Zhang Xian et al."Neurobehavioral alternations of the female offspring born to polycystic ovary syndrome model rats administered by Chinese herbal medicine."Chin Med-Uk. 2021 Dec;16(1):1-19 33. [IF=5.34] Tao-Fang Cheng et al."Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation."Phytomedicine. 2020 Dec;79:153330 34. [IF=4.879] Yang Liu et al."UV-B Radiation Largely Promoted the Transformation of Primary Metabolites to Phenols in Astragalus mongholicus Seedlings."Biomolecules. 2020 Apr;10(4):504 35. [IF=4.769] Zhenzhong Yang et al."Deciphering bioactive compounds of complex natural products by tandem mass spectral molecular networking combined with an aggregation-induced emission based probe."J Pharm Anal. 2020 Nov;: 36. [IF=4.225] Zhang Wei et al."Five Active Components Compatibility of Astragali Radix and Angelicae Sinensis Radix Protect Hematopoietic Function Against Cyclophosphamide-Induced Injury in Mice and t-BHP–Induced Injury in HSCs."Front Pharmacol. 2019 Aug;0:936 37. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 38. [IF=3.645] Jingbin Chen et al.Screening for potential quality markers of Callerya nitida var. hirsutissima. Z.Wei based on components profile, pharmacokinetics, and anti-inflammatory study.Journal Of Separation Science.2021 Nov 02 39. [IF=5.34] Lei Jin et al."Simultaneous optimization of the extraction process of Yangyin Yiqi Huoxue prescription with natural deep eutectic solvents for optimal extraction yield and antioxidant activity: A comparative study of two models."PHYTOMEDICINE. 2022 Jul;102 40. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 41. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure–Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 |
供应商列表
您刚刚浏览过
CALYCOSIN 毛蕊异黄酮 2-MERCAPTO-4-METHYLPYRIMIDINE HYDROCHLORIDE 1-丙基丁基溴化锌 (三甲基硅基)醋酸乙酯 4,8-Bis(hydroxymethyl)tricyclo[5.2.1.02,6]decane, mixture of isomers
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！